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Chemical Structure : NVP-BAW2881
CAS No.: 861875-60-7
Catalog No.: PC-42130Not For Human Use, Lab Use Only.
NVP-BAW2881 is a potent, selective VEGFR inhibitor with IC50 of 37 nM for hVEGFR2 (KDR).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 100 mg | $388 | In stock | |
| 200 mg | $588 | In stock | |
| 1 g | Get quote |
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NVP-BAW2881 is a potent, selective VEGFR inhibitor with IC50 of 37 nM for hVEGFR2 (KDR).
NVP-BAW2881 also demonstrates activity against Tie2 (IC50=650 nM) and RET (IC50=410 nM), no activity against a wide panel of other kinases.
NVP-BAW2881 inhibits VEGF-A-induced phosphorylation of VEGFR-2 in HUVECs and in VEGFR-2-transfected CHO cells with IC50 of 2.9 and 4.2 nM, respectively.
NVP-BAW2881 also inhibits phosphorylation of RET, PDGFRβ and c-Kit with IC50 of 40-80 nM.
NVP-BAW2881 inhibits the proliferation, migration and tube formation by HUVECs and lymphatic endothelial cells in vitro.
NVP-BAW2881 displays strong anti-inflammatory effects in models of acute inflammation such as psoriasis.
| M.Wt | 424.3753 | |
| Formula | C22H15F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
1-Naphthalenecarboxamide, 6-[(2-amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]- |
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1. Halin C, et al. Am J Pathol. 2008 Jul;173(1):265-77.
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