Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NVP-BHG712
CAS No.: 940310-85-0
Catalog No.: PC-43438Not For Human Use, Lab Use Only.
NVP-BHG712 is a potent, specific inhibitor of EphB4 kinase that inhibits EphB4 autophosphorylation with IC50 of 25 nM in cell-bases assays, displays little to no activity against VEGFR2, IGF1R and InsR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NVP-BHG712 is a potent, specific inhibitor of EphB4 kinase that inhibits EphB4 autophosphorylation with IC50 of 25 nM in cell-bases assays, displays little to no activity against VEGFR2, IGF1R and InsR.
NVP-BHG712 dose dependently inhibits autophosphorylation of the EphRs, showing some preference for EphB4 followed by inhibition of EphB2, EphA2, EphB3 and EphA3.
NVP-BHG712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration, inhibits VEGF driven tissue growth and angiogenesis in vivo.
| M.Wt | 503.48 | |
| Formula | C26H20F3N7O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzamide, 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]- |
|
1. Martiny-Baron G, et al. Angiogenesis. 2010 Sep;13(3):259-67.
2. Kathawala RJ, et al. Oncotarget. 2015 Jan 1;6(1):510-21.
3. Wnuk M, et al. Kidney Int. 2012 Jun;81(12):1212-25.
4. Becerikli M, et al. Int J Cancer. 2015 Apr 15;136(8):1781-91.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
