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Chemical Structure : NVP-HSP990
CAS No.: 934343-74-5
Catalog No.: PC-21200Not For Human Use, Lab Use Only.
NVP-HSP990 (HSP990) is a potent, selective, oral and brain-penetrant Hsp90 inhibitor with IC50 of 0.6, 0.8 and 8.5 nM for Hsp90α, Hsp90β and Grp94, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NVP-HSP990 (HSP990) is a potent, selective, oral and brain-penetrant Hsp90 inhibitor with IC50 of 0.6, 0.8 and 8.5 nM for Hsp90α, Hsp90β and Grp94, respectively.
NVP-HSP990 inhibits TRAP1 ATPase activity with IC50 of 320 nM, binds to the N-terminal ATP-binding domain of Hsp90.
NVP-HSP990 does not show significant binding or functional activities against a panel of 83 diverse receptors/enzymes involved in major physiologic functions.
NVP-HSP990 induces a signature response of Hsp90 inhibition and inhibits growth of a wide range of tumor cells.
NVP-HSP990 (5 mg/kg twice weekly or 15 mg/kg weekly) demonstrates antitumor efficacy in the GTL-16 gastric cancer model.
| M.Wt | 379.40 | |
| Formula | C20H18FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(7R)-2-amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-7,8-dihydro-4-methyl-pyrido[4,3-d]pyrimidin-5(6H)-one |
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1. Centenera MM, et al. Clin Cancer Res. 2012 Jul 1;18(13):3562-70.
2. Menezes DL, et al. Mol Cancer Ther. 2012 Mar;11(3):730-9.
3. Jackrel ME, et al. J Clin Invest. 2011 Aug;121(8):2972-5.
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