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Chemical Structure : NVR 3-778
Catalog No.: PC-35873Not For Human Use, Lab Use Only.
NVR 3-778 (NVR3-778, NVR 3778) is a small molecule inhibitor of HBV replication that targets the viral core protein, a first-in-class capsid assembly modulator.
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NVR 3-778 (NVR3-778, NVR 3778) is a small molecule inhibitor of HBV replication that targets the viral core protein, a first-in-class capsid assembly modulator; inhibits the generation of infectious HBV DNA containing virus particles with EC50 of 0.40 uM in HepG2.2.15 cells; NVR 3-778 inhibits pgRNA encapsidation, viral replication and the production of HBV DNA- and HBV RNA-containing particles, also inhibits de novo infection and viral replication in primary human hepatocytes with EC50 of 0.81 uM against HBV DNA and 3.7-4.8 uM against the production of HBV antigens and intracellular HBV RNA; demonstrates favorable pharmacokinetics and safety in animal species.
HBV Infection
Phase 1 Clinical
| M.Wt | 432.39 | |
| Formula | C18H16F4N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lam AM, et al. Antimicrob Agents Chemother. 2018 Oct 29. pii: AAC.01734-18.
2. Klumpp K, et al. Gastroenterology. 2018 Feb;154(3):652-662.e8.
3. Helsen N, et al. Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01497-18.
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