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Chemical Structure : NVS-PAK1-1
CAS No.: 1783816-74-9
Catalog No.: PC-49534Not For Human Use, Lab Use Only.
NVS-PAK1-1 is a potent, selective and allosteric inhibitor of PAK1 with IC50 of 5 nM, potently inhibits PAK1 phosphorylation in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $498 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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NVS-PAK1-1 is a potent, selective and allosteric inhibitor of PAK1 with IC50 of 5 nM, potently inhibits PAK1 phosphorylation in vitro and in vivo.
NVS-PAK1-1 is almost 100× more selective for PAK1 than PAK2.
NVS-PAK1-1 potently inhibited PAK1 autophosphorylation in MS02 cells, and reduced the proliferation of MS02 and HEI-193 cells with an IC50 of 4.7 and 6.2 μM, respectively.
NVS PAK1-1 (30 mg/kg) reduces the average dorsal root ganglia (DRG) size in Nf2-cKO mice.
| M.Wt | 479.932 | |
| Formula | C23H25ClF3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide |
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1. Chudi O Ndubaku, et al. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.
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