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Chemical Structure : NVS-STG2
Catalog No.: PC-21582Not For Human Use, Lab Use Only.
NVS-STG2 is a small molecule STING agonist with AC50 of 5.2 uM in ISRE-Luc reporter assays, induces STING-dependent IRF3 phosphorylation in THP1 cells.
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NVS-STG2 is a small molecule STING agonist with AC50 of 5.2 uM in ISRE-Luc reporter assays, induces STING-dependent IRF3 phosphorylation in THP1 cells.
NVS-STG2 targets STING transmembrane domain (TMD).
NVS-STG2 is a molecular glue promotes STING oligomerization, enhances the interface of the two STING dimers, thereby promoting the high-order oligomerization of STING.
NVS-STG2 activates human but not mouse STING.
NVS-STG2 induces antitumor activity and immune response in hSTING knock-in mice, exhibits a dose-dependent and significant induction of T cell priming response.
| M.Wt | 427.54 | |
| Formula | C25H33NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jie Li, et al. Nat Chem Biol. 2023 Oct 12. doi: 10.1038/s41589-023-01434-y.
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