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Chemical Structure : NVS-ZP7-4
CAS No.: 2349367-89-9
Catalog No.: PC-35995Not For Human Use, Lab Use Only.
NVS-ZP7-4 is specific small molecule inhibitor of SLC39A7 (ZIP7), inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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NVS-ZP7-4 is specific small molecule inhibitor of SLC39A7 (ZIP7), inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress.
The V430E mutation in ZIP7 can confer transferable resistance to the compound NVS-ZP7-4.
NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
| M.Wt | 501.624 | |
| Formula | C28H28FN5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-1-(2-((6-fluorobenzo[d]thiazol-2-yl)amino)-3-phenylpropyl)-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one |
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1. Nolin E, et al. Nat Chem Biol. 2019 Jan 14. doi: 10.1038/s41589-018-0200-7.
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