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Chemical Structure : NWL-117
Catalog No.: PC-70208Not For Human Use, Lab Use Only.
A potent Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.
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A potent Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM; shows weak activity against other Capase subutypes; inhibits Caspase-6 in Caspase-6-transfected HCT116 cells with IC50 of 4.82 uM; inhibits serum deprivation-induced Caspase-6 activity and prevents amyloid precursor protein-mediated neurite degeneration in human primary CNS neurons; BBB penetrant.
| M.Wt | 654.732 | |
| Formula | C29H42N4O11S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pakavathkumar P, et al. Mol Neurodegener. 2017 Feb 28;12(1):22.
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