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NXL101

Chemical Structure : NXL101

CAS No.: 904302-98-3

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NXL101 (NXL 101)

Catalog No.: PC-61939Not For Human Use, Lab Use Only.

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains.
    NXL101 inhibits S. aureus DNA gyrase and topoisomerase IV with IC50 of 1.0 and 18 uM, respectively.

    Physicochemical Properties

    M.Wt 504.635
    Formula C25H29FN2O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3R,4R)-4-[(3S)-3-(3-Fluoro-6-methoxy-4-quinolinyl)-3-hydroxypropyl]-1-[2-(2-thienylthio)ethyl]-3-piperidinecarboxylic acid

    References

    1. Black MT, et al. Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49.

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