Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Nacubactam
CAS No.: 2007923-17-1
Catalog No.: PC-62613Not For Human Use, Lab Use Only.
Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo.
Bacterial Infection
Phase 1 Clinical
| M.Wt | 342.323 | |
| Formula | C9H18N4O8S | |
| CAS No. | 2007923-17-1 | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name |
(2S, 5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, monohydrate |
|
1. Morinaka A, et al. J Antimicrob Chemother. 2015 Oct;70(10):2779-86.
2. Livermore DM, et al. J Antimicrob Chemother. 2015 Nov;70(11):3032-41.
3. Livermore DM, et al. Antimicrob Agents Chemother. 2015 Nov 9;60(1):554-60.
4. Morinaka A, et al. J Antibiot (Tokyo). 2017 Mar;70(3):246-250.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
