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Nacubactam

Chemical Structure : Nacubactam

CAS No.: 2007923-17-1

Nacubactam (OP 0595;RG 6080;RO 7079901)

Catalog No.: PC-62613Not For Human Use, Lab Use Only.

Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo.

    Bacterial Infection

    Phase 1 Clinical

    Physicochemical Properties

    M.Wt 342.323
    Formula C9H18N4O8S
    CAS No. 2007923-17-1
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name

    (2S, 5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, monohydrate

    References

    1. Morinaka A, et al. J Antimicrob Chemother. 2015 Oct;70(10):2779-86.

    2. Livermore DM, et al. J Antimicrob Chemother. 2015 Nov;70(11):3032-41.

    3. Livermore DM, et al. Antimicrob Agents Chemother. 2015 Nov 9;60(1):554-60.

    4. Morinaka A, et al. J Antibiot (Tokyo). 2017 Mar;70(3):246-250.

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