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Navoximod

Chemical Structure : Navoximod

CAS No.: 1402837-78-8

Navoximod (GDC-0917;CUDC427;CUDC 427;GDC0917;GDC 0917)

Catalog No.: PC-45552Not For Human Use, Lab Use Only.

Navoximod (GDC-0919, NLG-919) is a potent, selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with biochemical IC50 of 28 nM, and of Ki of 5.8 nM.

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Biological Activity

Navoximod (GDC-0919, NLG-919) is a potent, selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with biochemical IC50 of 28 nM, and of Ki of 5.8 nM.
NLG-919 inhibits IDO1 activity in an uncompetitive or a noncompetitive mode with respect to the l-Trp substrate.
NLG-919 (500 mg/kg/day) reduced tumor growth and enhance survival as a single agent in Pan02 tumor model in C57Bl/6 mice.

Physicochemical Properties

M.Wt 316.3699
Formula C18H21FN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO

Chemical Name/SMILES

5H-Imidazo[5,1-a]isoindole-5-ethanol, 6-fluoro-α-(trans-4-hydroxycyclohexyl)-, (αR,5S)-

References

1. Mautino, et al. Preparation of fused imidazole derivatives as IDO inhibitors. From PCT Int. Appl. (2012), 20121018.
2. Kumar S, et al. J Med Chem. 2019 Jul 25;62(14):6705-6733.

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