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Chemical Structure : Nebicapone
CAS No.: 274925-86-9
Catalog No.: PC-35791Not For Human Use, Lab Use Only.
Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM.
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| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
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| 1 g | Get quote |
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Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM.
Nebicapone (BIA 3-202, BIA3-202) enhances the availability of L-DOPA to the brain and reduces its O-methylation.
Nebicapone (BIA 3-202, BIA3-202) is an adjunct to levodopa/carbidopa or levodopa/benserazide in the treatment of Parkinson's disease.
| M.Wt | 273.244 | |
| Formula | C14H11NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethan-1-one |
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1. Parada A, et al. Pharmacology. 2003 May;68(1):29-37.
2. Bonifácio MJ, et al. Eur J Pharmacol. 2003 Jan 24;460(2-3):163-70.
3. Learmonth DA, et al. J Med Chem. 2002 Jan 31;45(3):685-95.
4. Parada A, et al. Eur J Pharmacol. 2001 May 18;420(1):27-32.
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