Necrostatin-5 | Necroptosis inhibitor, RIPK1 inhibitor

Chemical Structure : Necrostatin-5

CAS No.: 337349-54-9

Necrostatin-5 (Nec-5)

Catalog No.: PC-22668Not For Human Use, Lab Use Only.

Necrostatin-5 (Nec-5) is a potent, specific necroptosis inhibitor with EC50 of 240 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1).

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Biological Activity

Necrostatin-5 (Nec-5) is a potent, specific necroptosis inhibitor with EC50 of 240 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1).

Physicochemical Properties

M.Wt	383.48
Formula	C19H17N3O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile

References

1. Degterev A, et al. Nat Chem Biol. 2008 May;4(5):313-21.

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Necrostatin-5 (Nec-5)

Biological Activity

Physicochemical Properties

References

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