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Nelonicline

Chemical Structure : Nelonicline

CAS No.: 1026134-63-3

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Nelonicline (ABT-126, ABT126)

Catalog No.: PC-35624Not For Human Use, Lab Use Only.

Nelonicline (ABT-126) is a potent, selective α7 nicotinic receptor (α7 nAChR) partial agonist with binding Ki of 12.3 nM in human brain, shows potential for the treatment of cognitive impairment with schizophrenia.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Nelonicline (ABT-126) is a potent, selective α7 nicotinic receptor (α7 nAChR) partial agonist with binding Ki of 12.3 nM in human brain, shows potential for the treatment of cognitive impairment with schizophrenia.

    Physicochemical Properties

    M.Wt 312.431
    Formula C18H20N2OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(((5S,7S)-adamantan-2-yl)oxy)-5-phenyl-1,3,4-thiadiazole

    References

    1. Gault LM, et al. Alzheimers Dement (N Y). 2015 Jun 23;1(1):81-90.

    2. Hashimoto K. Curr Pharm Des. 2015;21(26):3797-806.

    3. Zhang D, et al. Mov Disord. 2015 Dec;30(14):1901-1911.

    4. Haig G, et al. Neuropsychopharmacology. 2016 Nov;41(12):2893-2902.

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