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Chemical Structure : Nepicastat
CAS No.: 173997-05-2
Catalog No.: PC-43466Not For Human Use, Lab Use Only.
Nepicastat (RS-25560-197, SYN-117) is a potent, selective, orally active inhibitor of dopamine-beta-hydroxylase (DBH) with IC50 of 8.5 and 9.0 nM for bovine and human DBH, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $75 | In stock | |
| 25 mg | $165 | In stock | |
| 100 mg | $425 | In stock | |
| 500 mg | Get quote |
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Nepicastat (RS-25560-197, SYN-117) is a potent, selective, orally active inhibitor of dopamine-beta-hydroxylase (DBH) with IC50 of 8.5 and 9.0 nM for bovine and human DBH, respectively; Nepicastat is 2-3 fold more potent than the corresponding R-enantiomer (RS-25560-198); produces dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery, left ventricle and cerebral cortex in spontaneously hypertensive rats.
Hypertension
Discontinued
| M.Wt | ||
| Formula | C14H15F2N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 48 mg/mL |
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| Chemical Name/SMILES |
2H-Imidazole-2-thione, 5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro- |
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1. Stanley WC, et al. Br J Pharmacol. 1997 Aug;121(8):1803-9.
2. Stanley WC, et al. J Cardiovasc Pharmacol. 1998 Jun;31(6):963-70.
3. Sabbah HN, et al. Circulation. 2000 Oct 17;102(16):1990-5.
4. Schroeder JP, et al. Neuropsychopharmacology. 2010 Nov;35(12):2440-9.
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