Chemical Structure : Netarsudil
CAS No.: 1254032-66-0
Catalog No.: PC-62714Not For Human Use, Lab Use Only.
Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.
Packing | Price | Stock | Quantity |
---|---|---|---|
25 mg | $185 | In stock | |
100 mg | $385 | In stock | |
250 mg | $585 | In stock | |
1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; 11 kinases are inhibited >90% in a panel of 422 kinases, only ROCK1 and ROCK2 (each 93% inhibition) and PKC (delta, 91%, and eta, 93% inhibition); exhibts improved bioavailability, demonstrates an effective and sustained IOP reduction for 24h after dosing; a novel ocular hypotensive agent for the treatment of glaucoma.
Other Indication
Approved
M.Wt | 453.54 | |
Formula | C28H27N3O3 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate |
1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80.
2. Li G, et al. Eur J Pharmacol. 2016 Sep 15;787:20-31.
3. Lin CW, et al. J Ocul Pharmacol Ther. 2017 Jun 13. doi: 10.1089/jop.2017.0023.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright