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Neutrophil elastase inhibitor PD05

Chemical Structure : Neutrophil elastase inhibitor PD05

CAS No.: 3033318-13-4

Neutrophil elastase inhibitor PD05 (PD05)

Catalog No.: PC-49231Not For Human Use, Lab Use Only.

Neutrophil elastase inhibitor PD05 is a potent selective and reversible human neutrophil elastase (HNE) inhibitor with Kd of 1.63 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Neutrophil elastase inhibitor PD05 is a potent selective and reversible human neutrophil elastase (HNE) inhibitor with Kd of 1.63 nM.
    Neutrophil elastase inhibitor PD05 reduces the alveolar collapse induced by neutrophil elastase in mouse model of COPD.

    Physicochemical Properties

    M.Wt 225.628
    Formula C10H8ClNO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(1-chloroethoxy)-4H-benzo[d][1,3]oxazin-4-one

    References

    1. Sayantan Sengupta, et al. Eur J Pharmacol. 2022 Aug 8;931:175187.

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