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Chemical Structure : Nexinhib 20
Catalog No.: PC-60847Not For Human Use, Lab Use Only.
Nexinhib 20 is a novel small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors.
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Nexinhib 20 is a novel small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors.
Nexinhib 20 does not induce apoptosis or cell death, regulates exocytosis-dependent neutrophil functions and inhibits MPO secretion from human neutrophils.
Nexinhib 20 also reversiblely and potently inhibits extracellular production of superoxide anion and the up-regulation of activation signature molecules, including CD11b and CD66b.
Nexinhib 20 significantly decreased tissue infiltration by inflammatory neutrophils in vivo.
| M.Wt | 300.318 | |
| Formula | C15H16N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Johnson JL, et al. J Biol Chem. 2016 Dec 9;291(50):25965-25982.
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