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Nivolumab

Chemical Structure : Nivolumab

CAS No.:

Nivolumab (Anti-human PD-1 mAb, human IgG4 (S228P)-Kappa)

Catalog No.: PC-Ab1008Not For Human Use, Lab Use Only.

Nivolumab binds to the extracellular portion of human PD-1 (2.6 nM - Scatchard analysis and SPR) - the antibody also binds to cynomolgus PD-1 with a similar affinity (3.9 nM - SPR). The antibody does not bind to other immunoglobulin superfamily proteins such as CD28, CTLA-4, ICOS and BTLA. Nivolumab enhances immune response against various cancers. .

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nivolumab binds to the extracellular portion of human PD-1 (2.6 nM - Scatchard analysis and SPR) - the antibody also binds to cynomolgus PD-1 with a similar affinity (3.9 nM - SPR). The antibody does not bind to other immunoglobulin superfamily proteins such as CD28, CTLA-4, ICOS and BTLA. Nivolumab enhances immune response against various cancers.

Physicochemical Properties

M.Wt
Formula Human IgG4 (S228P)-Kappa
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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