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Chemical Structure : Nobiletin
CAS No.: 478-01-3
Catalog No.: PC-63473Not For Human Use, Lab Use Only.
Nobiletin is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment, also is a clock modulator that targets RORα/γ.
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| 50 mg | $138 | In stock | |
| 100 mg | $218 | In stock | |
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Nobiletin is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment, also is a clock modulator that targets RORα/γ.
Nobiletin induces neurite outgrowth of PC12D cells, causes a concentration-dependent enhancement of Erk/MAP kinase phosphorylation and a sustained increment of phosphorylation of MEK and Erk/MAP kinase.
Nobiletin also preferentially inhibits Ca2+/CaM-dependent phosphodiesterase in vitro.
Nobiletin enhances the clock and concordantly renders protection against metabolic syndrome in a Clock gene-dependent manner, enhances RORα/γ transcriptional activity via direct binding to RORα/γ.
| M.Wt | 402.399 | |
| Formula | C21H22O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3',4',5,6,7,8-Hexamethoxyflavone |
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1. Nagase H, et al. Biochemistry. 2005 Oct 25;44(42):13683-91.
2. He B, et al. Cell Metab. 2016 Apr 12;23(4):610-21.
3. Nakajima A, et al. J Pharmacol Sci. 2007 Sep;105(1):122-6.
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