OAB-14

Chemical Structure : OAB-14

Catalog No.: PC-24359Not For Human Use, Lab Use Only.

OAB-14 is a bexaroten derivative that reduces the deposition of Aβ, promotes microglia phagocytosis and increasing IDE and NEP expression.

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Biological Activity

OAB-14 is a bexaroten derivative that reduces the deposition of Aβ, promotes microglia phagocytosis and increasing IDE and NEP expression.
OAB-14 significantly alleviates cognitive impairments in amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mice.
OAB-14 rapidly cleared 71% of Aβ by promoting microglia phagocytosis and increasing IDE and NEP expression.
OAB-14 also attenuated the downstream pathological events of Aβ accumulation, such as synaptic degeneration, neuronal loss, tau hyperphosphorylation and neuroinflammation in APP/PS1 mice.
OAB-14 may promote the clearance of brain α-syn through the glial lymphatic system, inhibit the α-syn/TLR4/NF-κB/NLRP3 inflammatory pathway, and improve movement disorders.

Physicochemical Properties

M.Wt	518.75
Formula	C32H46N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 4-[[[(2-aminoethyl)amino]carbonyl]amino]-N-(1,2,3,4,5,6,7,8-octahydro-1,1,4,4,5,5,8,8-octamethyl-9-anthracenyl)-

References

1. Yuan C, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):161-180.

2. Guo X, et al. ACS Chem Neurosci. 2021 Nov 3;12(21):3985-3993.

OAB-14

Biological Activity

Physicochemical Properties

References

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