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OAC1

Chemical Structure : OAC1

CAS No.: 300586-90-7

OAC1 (OAC-1;Oct4-activating compound 1)

Catalog No.: PC-42966Not For Human Use, Lab Use Only.

Oct4-activating compound 1 (OAC1) is a small molecule Oct4-activating compound, enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Oct4-activating compound 1 (OAC1) is a small molecule Oct4-activating compound, enhances the iPSC reprogramming efficiency and accelerates the reprogramming process; activates Oct4 and Nanog promoter-driven reporters in triplicate luciferase reporter assays, activates endogenous Oct4, Nanog, Sox2, and Tet1 expression; enhances reprogramming about fourfold at day 8 at 1 uM in iSF1 for the generation of mouse iPSCs.

Physicochemical Properties

M.Wt 237.2566
Formula C14H11N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 40 mg/mL

Chemical Name/SMILES

Benzamide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-

References

1. Li W, et al. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8.

2. Huang X, et al. Leukemia. 2016 Jan;30(1):144-53.

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