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Chemical Structure : OAT-1441
Catalog No.: PC-72372Not For Human Use, Lab Use Only.
OAT-1441 (OAT1441) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 7 nM.
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OAT-1441 (OAT1441) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 7 nM.
OAT-1441 displays high activity and selectivity toward hAMCase over hCHIT1 (131-fold), significantly reduced off-target activity toward hERG (IC50>20 uM).
OAT-1441 is a useful tool compound to study the physiological role of hAMCase.
| M.Wt | 438.96 | |
| Formula | C23H27ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gleb Andryianau, et al. ACS Med Chem Lett. 2020 Apr 24;11(6):1228-1235.
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