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Chemical Structure : OAT-1746
Catalog No.: PC-61993Not For Human Use, Lab Use Only.
OAT-1746 (OATD-02) is a novel potent, selective, orally active inhibitors of Arginase 1 and 2 (ARG1/2) with IC50 of 20 nM and 39 nM for hARG1 and hARG2, respectively.
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OAT-1746 (OATD-02) is a novel potent, selective, orally active inhibitors of Arginase 1 and 2 (ARG1/2) with IC50 of 20 nM and 39 nM for hARG1 and hARG2, respectively.
OAT-1746 (OATD-02) reverses the ARG1-inhibited proliferation of human and murine T cells and restored CD3ζ expression in ex vivo assays.
OAT-1746 (OATD-02) demonstrates antitumor activity alone or in combination with checkpoint inhibitors and gemcitabine in vivo.
| M.Wt | 272.15 | |
| Formula | C12H25BN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Borek B, et al. Mol Cancer Ther. 2023 Mar 20:MCT-22-0721.
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