Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : OAT-177
Catalog No.: PC-62540Not For Human Use, Lab Use Only.
OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1.
OAT-177 shows significant anti-inflammatory efficacy in HDM-induced allergic airway inflammation in mice at 30 mg/kg po.
OAT-177 reduces inflammatory cell influx in the BALF and total IgE concentration in plasma.
| M.Wt | 376.933 | |
| Formula | C19H29ClN6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Mazur M, et al. J Med Chem. 2018 Feb 8;61(3):695-710.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
