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Chemical Structure : OBP-801
Catalog No.: PC-61957Not For Human Use, Lab Use Only.
OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.
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OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM; significantly inhibits the cell growth on comparison with each agent alone and synergistically increased apoptosis with the induction of Bim; significantly suppresses tumor growth in vivo.
Kidney Cancer
Phase 1 Clinical
| M.Wt | 473.603 | |
| Formula | C20H31N3O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shindoh N, et al. Int J Oncol. 2008 Mar;32(3):545-55.
2. Yoshioka T, et al. Gynecol Oncol. 2013 May;129(2):425-32.
3. Furutani A, et al. Oncol Res. 2014;21(5):281-6.
4. Akiyama M, et al. Oncol Res. 2017 Sep 21;25(8):1245-1252.
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