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OBP-801

Chemical Structure : OBP-801

CAS No.: 328548-11-4

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OBP-801 (OBP801, YM 753, Spiruchostatin A)

Catalog No.: PC-61957Not For Human Use, Lab Use Only.

OBP-801 (YM 753, Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OBP-801 (YM 753, Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.
    OBP-801 significantly inhibits the cell growth on comparison with each agent alone and synergistically increased apoptosis with the induction of Bim,
    OBP-801 significantly suppresses tumor growth in vivo.

    Physicochemical Properties

    M.Wt 473.603
    Formula C20H31N3O6S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1S,5S,6R,9S,20R,E)-5-hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetraone

    References

    1. Shindoh N, et al. Int J Oncol. 2008 Mar;32(3):545-55.

    2. Yoshioka T, et al. Gynecol Oncol. 2013 May;129(2):425-32.

    3. Furutani A, et al. Oncol Res. 2014;21(5):281-6.

    4. Akiyama M, et al. Oncol Res. 2017 Sep 21;25(8):1245-1252.

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