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Chemical Structure : OHM1
Catalog No.: PC-62483Not For Human Use, Lab Use Only.
OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells.
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OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells; reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals.
| M.Wt | 494.637 | |
| Formula | C24H42N6O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
2. Lao BB, et al. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7531-6.
3. Fang Y, et al. Exp Cell Res. 2007 Mar 10;313(5):867-77.
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