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OICR-41103

Chemical Structure : OICR-41103

CAS No.:

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OICR-41103 (OICR41103)

Catalog No.: PC-25147Not For Human Use, Lab Use Only.

OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein.
shows no affinity for a panel of six WDR proteins up to 20 uM.
OICR-41103 binds and engages the WDR domain of DCAF1 in cells, effectively thermally stabilized the WDR domain of DCAF1 with EC50 of 165 nM.
OICR-41103 displaces HIV viral accessory protein Vpr from the DCAF1 WDR domain.

Physicochemical Properties

M.Wt 575.44
Formula C28H26Cl2F2N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S,E)-N-(3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl)-4-(4-chloro-2-fluorophenyl)-5-(3-oxo-3-(piperidin-1-yl)prop-1-en-1-yl)-1H-pyrrole-3-carboxamide

References

1. Kimani SW, et al. Commun Biol. 2025 Jul 19;8(1):1076.

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