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OJI-1

Chemical Structure : OJI-1

CAS No.: 1620779-53-4

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OJI-1 (OJI1)

Catalog No.: PC-27743Not For Human Use, Lab Use Only.

OJI-1 is a potent, selective HDAC8 inhibitor with IC50 of 0.8 nM, mildly inhibits HDAC6 and HDAC1 with IC50s of 1.2 uM and 4.3 uM, does not inhibit other HDACs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OJI-1 is a potent, selective HDAC8 inhibitor with IC50 of 0.8 nM, mildly inhibits HDAC6 and HDAC1 with IC50s of 1.2 uM and 4.3 uM, does not inhibit other HDACs.

Physicochemical Properties

M.Wt 372.43
Formula C22H20N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

References

1. Oscar J Ingham, et al. ACS Med Chem Lett. 2016 Sep 1;7(10):929-932.

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