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Chemical Structure : OJT008
Catalog No.: PC-21577Not For Human Use, Lab Use Only.
OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb.
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OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb.
OJT008 inhibits MtMetAP1c activated with CoCl2 and NiCl2 were 11 µM and 40 µM, respectively, strongly binds to both metal-activated MtMetAP1c.
OJT008 also inhibits the enzyme methionine aminopeptidase 1 of L. major (MetAP1Lm).
OJT008 showed potent leishmanicidal activity and remarkable selectivity indexes in vitro (EC50=0.24 uM).
OJT008 exhibits significant antileishmanial activity in vitro and in vivo.
| M.Wt | 324.81 | |
| Formula | C18H17ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rodriguez F, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e01422-19.
2. Onyenaka C, et al. Int J Mol Sci. 2023 Dec 5;24(24):17142.
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