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Chemical Structure : OM-153
Catalog No.: PC-38617Not For Human Use, Lab Use Only.
OM-153 (OM153) is a potent, selective tankyrase 1 and 2 (TNKS1/2) inhibitor with IC50 of 13 nM and 2 nM, respectively, specifically inhibits WNT/β-catenin signaling with IC50 of 0.63 nM, does not inhibit PARP1.
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OM-153 (OM153) is a potent, selective tankyrase 1 and 2 (TNKS1/2) inhibitor with IC50 of 13 nM and 2 nM, respectively, specifically inhibits WNT/β-catenin signaling with IC50 of 0.63 nM, does not inhibit PARP1.
OM-153 inhibits cell growth in the APC-mutated colon carcinoma cell line COLO 320DM with GI50 of 10 nM.
OM-153 inhibits WNT/β-catenin, YAP, and MYC signaling and shows an antiproliferative effect in human cancer cell lines.
OM-153 induces formation of β-catenin and AXIN1-containing puncta and reduces nuclear β-catenin in COLO 320DM cells.
OM-153 (i.v., 0.4 or 2 mg/kg) or oral (p.o., 10 or 100 mg/kg) inhibits WNT/β-catenin signaling and shows antitumor effect in a human colon carcinoma xenograft model.
| M.Wt | 509.545 | |
| Formula | C28H24FN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ruben G G Leenders, et al. J Med Chem. 2021 Dec 23;64(24):17936-17949.
2. Shoshy A. Brinch, et al. Cancer Research Communications (2022) 2 (4): 233–245.
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