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Chemical Structure : ONO-1301
Catalog No.: PC-60721Not For Human Use, Lab Use Only.
A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.
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A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase; suppresses the elevation of protein excretion into urine in rats, attenuates the development of bleomycin-induced pulmonary fibrosis and improves survival in bleomycin mice.
Thrombosis
Discontinued
| M.Wt | 428.488 | |
| Formula | C26H24N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hayashi K, et al. Jpn J Pharmacol. 1997 Jan;73(1):73-82.
2. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90.
3. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84.
4. Murakami S, et al. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L59-65.
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