Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ONO-2952
Catalog No.: PC-60732Not For Human Use, Lab Use Only.
ONO-2952 is a novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3 nM for both rat and human TSPO, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ONO-2952 is a novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3 nM for both rat and human TSPO, respectively.
ONO-2952 displays high selectivity over 98 other receptors, transporters, ion channels and enzymes.
ONO-2952 inhibits both neurosteroid accumulation and noradrenaline release in the brain of rats exposed to acute stress.
ONO-2952 suppresses conditioned fear stress-induced freezing behavior in rats with an efficacy equivalent to that of diazepam, but without not affect learning and memory.
| M.Wt | 398.862 | |
| Formula | C22H20ClFN2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Mitsui K, et al. Neuropharmacology. 2015 Dec;99:51-66.
2. Mitsui K, et al. J Pharmacol Exp Ther. 2017 Mar;360(3):457-465.
3. Frankle WG, et al. Synapse. 2017 Jul;71(7).
4. Mitsui K, et al. Neuropharmacology. 2015 Dec;99:51-66.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
