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Chemical Structure : ONO-4578
Catalog No.: PC-20853Not For Human Use, Lab Use Only.
ONO-4578 (BMS-986310) is a potent, highly selective EP4 antagonist, potently inhibits the PGE2-induced cAMP production in CHO cells expressing mouse and human EP4 receptors with single-digit nM IC50.
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ONO-4578 (BMS-986310) is a potent, highly selective EP4 antagonist, potently inhibits the PGE2-induced cAMP production in CHO cells expressing mouse and human EP4 receptors with single-digit nM IC50.
ONO-4578 (BMS-986310) shows excellent pharmacokinetic properties after oral dosing in mouse.
ONO-4578 (BMS-986310) reverses PGE2-mediated suppression of T cell activation and promotes DC differentiation in vitro.
ONO-4578 (BMS-986310) inhibits growth of CT26 and MC38 tumors in syngeneic mouse, significantly prolongs survival of mice with highly aggressive SB28 gliomas in the brain.
ONO-4578 (BMS-986310) reduces infiltration of M2 macrophages in MC38 tumors compared with control mice.
A combination of ONO-4578 (BMS-986310) and anti-PD-1 antibody results in enhanced anti-tumor effects in GL261 and MC38 tumor-bearing mice compared with anti-PD-1 monotherapy.
| M.Wt | 475.55 | |
| Formula | C27H29N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tohru Kotani, et al. Cancer Res (2020) 80 (16_Supplement): 4443.
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