Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ONO-7475
CAS No.: 1646839-59-9
Catalog No.: PC-73130Not For Human Use, Lab Use Only.
ONO-7475 (ONO7475) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $18 | In stock | |
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ONO-7475 (ONO7475) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations.
ONO-7475 sensitizes AXL-expressing EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib.
ONO-7475 suppresses the emergence and maintenance of EGFR-TKI-tolerant cells, suppresses the phosphorylation of AKT, p70S6K, ERK, as well as EGFR.
Combination therapy of ONO-7475 and osimertinib delays regrowth of cell line-derived xenograft tumors.
Osimertinib-acquired resistant cells are insensitive to combined therapy with osimertinib and ONO-7475.
| M.Wt | 562.582 | |
| Formula | C32H26N4O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide |
|
1. Okura N, et al. Clin Cancer Res. 2020 May 1;26(9):2244-2256.
2. Ruvolo PP, et al. Haematologica. 2017 Dec;102(12):2048-2057.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
