Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ONO-8430506
CAS No.: 1354805-08-5
Catalog No.: PC-38743Not For Human Use, Lab Use Only.
ONO-8430506 is a highly potent, orally available autotaxin (ATX) inhibitor with IC50 of 10 nM (recombinant human ATX), exhibits LysoPLD inhibitory activity in human plasma with IC50 of 5.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ONO-8430506 is a highly potent, orally available autotaxin (ATX) inhibitor with IC50 of 10 nM (recombinant human ATX), exhibits LysoPLD inhibitory activity in human plasma with IC50 of 5.5 nM.
ONO-8430506 suppressed LPA formation in plasma and decreased rat intraurethral pressure in a dose-dependent manner。
ONO-8430506 enhances the antitumor effect of paclitaxel in breast cancer model.
ONO-8430506 (30 mg/kg) ameliorates neuropathic pain derived from lumbar spinal canal stenosis.
| M.Wt | 461.53 | |
| Formula | C27H28FN3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-[2-[9-[(4-Fluorophenyl)methyl]-5,6,8,9-tetrahydro-7H-pyrrolo[2,3-b:5,4-c′]dipyridin-7-yl]-2-oxoethyl]bicyclo[2.2.1]heptane-1-carboxylic acid |
|
1. Iwaki Y, et al. ACS Med Chem Lett. 2020 May 14;11(6):1335-1341.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
