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Chemical Structure : OPB-51602
Catalog No.: PC-70276Not For Human Use, Lab Use Only.
A novel small molecule SH2 domain-targeting STAT3 inhibitor with IC50/Kd of 7.3/5 nM.
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A novel small molecule SH2 domain-targeting STAT3 inhibitor with IC50/Kd of 7.3/5 nM; does not bind to the S636A, V637A, and E638A SH2D mutants; effectively inhibits STAT3 phosphorylation (pTyr705 and pSer727) and cancer cell proliferation, impairs mitochondrial function; shows potent activity tumor xenografts in mice; orally bioactive.
Blood Cancer
Phase 1 Clinical
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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