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Chemical Structure : OSI-027
CAS No.: 936890-98-1
Catalog No.: PC-42577Not For Human Use, Lab Use Only.
OSI-027 is a potent and selective inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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OSI-027 is a potent and selective inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.
OSI-027 displays >100-fold selectivity for mTOR over PI3Kα, PI3Kβ, PI3Kγ, and DNA-PK.
OSI-027 inhibits phosphorylation of the mTORC1 substrates 4E-BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo.
OSI-027 demonstrates robust antitumor activity in human xenograft models.
| M.Wt | 406.4378 | |
| Formula | C21H22N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclohexanecarboxylic acid, 4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-, trans- |
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1. Carayol N, et al. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12469-74.
2. Falcon BL, et al. Cancer Res. 2011 Mar 1;71(5):1573-83.
3. Altman JK, et al. Clin Cancer Res. 2011 Jul 1;17(13):4378-88.
4. Bhagwat SV, et al. Mol Cancer Ther. 2011 Aug;10(8):1394-406.
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