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OSSK-674842

Chemical Structure : OSSK-674842

CAS No.: 2054944-80-6

OSSK-674842 (OSSK-2;OSSK 674842)

Catalog No.: PC-70167Not For Human Use, Lab Use Only.

A novel potent CFTR potentiator that blocks hCFTR with apparent Kd of 71.3 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel potent CFTR potentiator that blocks hCFTR with apparent Kd of 71.3 uM; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.

Cystic Fibrosis

Preclinical

Physicochemical Properties

M.Wt 457.122
Formula C16H15Br2N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide

References

1. Cui G, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L192-207.

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