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Chemical Structure : OSU-03012
CAS No.: 742112-33-0
Catalog No.: PC-60605Not For Human Use, Lab Use Only.
OSU-03012 (AR-12) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $58 | In stock | |
| 25 mg | $148 | In stock | |
| 100 mg | $388 | In stock | |
| 500 mg | Get quote |
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OSU-03012 (AR-12) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 5 uM; induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity; displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3 uM; decreases incidences of carcinoma and metastasis in transgenic mouse model of prostate cancer.
Blood Cancer
Phase 1 Clinical
| M.Wt | ||
| Formula | ||
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide |
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1. Johnson AJ, et al. Blood. 2005 Mar 15;105(6):2504-9.
2. Tseng PH, et al. Blood. 2005 May 15;105(10):4021-7.
3. Zhu J, et al. Cancer Res. 2004 Jun 15;64(12):4309-18.
4. Baryawno N, et al. Cancer Res. 2010 Jan 1;70(1):266-76.
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