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OTX008

Chemical Structure : OTX008

CAS No.: 286936-40-1

OTX008 (Calixarene 0118;PTX-008)

Catalog No.: PC-61646Not For Human Use, Lab Use Only.

OTX008 (Calixarene 0118, PTX-008) is a is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
OTX008 inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways, and induces G2/M cell cycle arrest through CDK1.
OTX008 inhibits proliferation and invasion at micromolar concentrations in cancer cells.
OTX008 inhibits growth of A2780-1A9 xenografts in vivo.

Physicochemical Properties

M.Wt 937.18
Formula C52H72N8O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Acetamide, 2,​2',​2'',​2'''-​[(2-​methylpentacyclo[19.​3.1.13,​7.19,​13.115,​19]​octacosa-​1(25)​,​3,​5,​7(28)​,​9,​11,​13(27)​,​15,​17,​19(26)​,​21,​23-​dodecaene-​25,​26,​27,​28-​tetrayl)​tetrakis(oxy)​]​tetrakis[N-​[2-​(dimethylamino)​ethyl]​-

References

1. Dings RP, et al. J Med Chem. 2012 Jun 14;55(11):5121-9.

2. Astorgues-Xerri L, et al. Eur J Cancer. 2014 Sep;50(14):2463-77.

3. Dings RP, et al. Cancer Lett. 2008 Jul 8;265(2):270-80.

4. Zucchetti M, et al. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87.

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