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Chemical Structure : Ociperlimab
Catalog No.: PC-38834Not For Human Use, Lab Use Only.
Ociperlimab (BGB-A1217) is a novel humanized IgG1 anti-TIGIT antibody (mAb) with anti-tumor activities.
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Ociperlimab (BGB-A1217) is a novel humanized IgG1 anti-TIGIT antibody (mAb) with anti-tumor activities.
BGB-A1217 binds to the extracellular domain of human TIGIT with high affinity (KD=0.135 nM) and specificity, and efficiently blocks the interaction between TIGIT and its ligands PVR or PVR-L2.
BGB-A1217 significantly enhances T-cell functions in cell-based assays.
BGB-A1217 induces antibody dependent cellular cytotoxicity (ADCC) against Treg cells, activates NK cells and monocytes, and removes TIGIT from T cell surfaces in an Fc-dependent manner.
BGB-A1217, either alone or in combination with an anti-PD-1 mAb elicits strong immune responses and potent anti-tumor efficacy in pre-clinical models.
Isotype: IgG1-kappa.
Anti-[human TIGIT (T-cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane
member 3, VSTM3)], humanized monoclonal antibody.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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