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Odronextamab

Chemical Structure : Odronextamab

CAS No.:

Odronextamab (Anti-human CD20 CD3 bispecific mAb, human IgG4-Kappa; REGN19179)

Catalog No.: PC-Ab1035Not For Human Use, Lab Use Only.

Odronextamab (REGN1979) is a first-in-class, hinge-stabilized, fully human IgG4-based CD3 x CD20 bispecific antibody (bsAb), binds to CD20-expressing cells and CD3 on T cells, targeting CD20+ cells via T-cell-mediated cytotoxicity independent of T-cell receptor recognition. Odronextamab has demonstrated preliminary efficacy in relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL)..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Odronextamab (REGN1979) is a first-in-class, hinge-stabilized, fully human IgG4-based CD3 x CD20 bispecific antibody (bsAb), binds to CD20-expressing cells and CD3 on T cells, targeting CD20+ cells via T-cell-mediated cytotoxicity independent of T-cell receptor recognition. Odronextamab has demonstrated preliminary efficacy in relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL).

Physicochemical Properties

M.Wt
Formula Human IgG4-Kappa
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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