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Chemical Structure : Olokizumab
Catalog No.: PC-38886Not For Human Use, Lab Use Only.
Olokizumab is a humanized antibody targeting interleukin-6 (IL-6), binds to IL-6 at Site 3 and neutralizes biological activity through blocking hexamer formation on the gp130 signaling axis.
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|---|---|---|---|
| 1 mg | Get quote | ||
| 5 mg | Get quote | ||
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Olokizumab is a humanized antibody targeting interleukin-6 (IL-6), binds to IL-6 at Site 3 and neutralizes biological activity through blocking hexamer formation on the gp130 signaling axis.
Olokizumab binds to human IL-6 with an affinity (KD) of 10 pM.
Olokizumab selectively blocks the final assembly of the IL-6 signaling complex.
Olokizumab shows potential for inflammatory disease e.g. rheumatoid arthritis, as well as current SARS-CoV-2 infection.
Isotype: IgG4-kappa.
Anti-[human IL6;interleukin 6 (interferon, beta 2);IFNB2;interleukin-6;BSF2;HGF;HSF;IL 6;CDF;BSF-2;IFN-beta-2;interferon beta-2;interleukin BSF-2;hybridoma growth factor;CTL differentiation factor;B-cell stimulatory factor 2], human monoclonal antibody.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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