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Chemical Structure : Oltipraz
CAS No.: 64224-21-1
Catalog No.: PC-43087Not For Human Use, Lab Use Only.
Oltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth, inhibits insulin- or hypoxia-induced HIF-1α expression through an increase in ubiquitination.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $75 | In stock | |
| 100 mg | $125 | In stock | |
| 200 mg | $165 | In stock | |
| 500 mg | $215 | In stock |
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Oltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth, inhibits insulin- or hypoxia-induced HIF-1α expression through an increase in ubiquitination; abrogates insulin-induced H(2)O(2) production, thereby preventing H(2)O(2)-enhanced HIF-1alpha expression and promoting its ubiquitination and degradation; inhibits HIF-1α activity and HIF-1α-dependent tumor growth both in vitro and in vivo.
Steatohepatitis
Phase 3 Clinical
| M.Wt | 226.3416 | |
| Formula | C8H6N2S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3H-1,2-Dithiole-3-thione, 4-methyl-5-(2-pyrazinyl)- |
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1. Lee WH, et al. Mol Cancer Ther. 2009 Oct;8(10):2791-802.
2. Kang SG, et al. Carcinogenesis. 2012 Mar;33(3):661-9.
3. Lee YH, et al. Bioorg Med Chem. 2016 Jun 15;24(12):2843-51.
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