Catalog No.: PC-25124Not For Human Use, Lab Use Only.
Onalespib (AT13387) is a highly potent HSP90 inhibitor with Ki of 0.71 nM by binding in the ATPase site at the N-terminus of Hsp90, inhibits HCT116 cell proliferation with IC50 of 48 nM.
Onalespib (AT13387) is a highly potent HSP90 inhibitor with Ki of 0.71 nM by binding in the ATPase site at the N-terminus of Hsp90, inhibits HCT116 cell proliferation with IC50 of 48 nM. Onalespib (AT13387) potently inhibits the expression of the oncogenic client proteins Raf-1 and CDK4 at 30 nM in the HCT116 cell line. Onalespib (AT13387) potently inhibits the proliferation of a panel of human tumor cell lines (well over 100 cell lines have been tested), showing IC50 < 100 nM. Onalespib (AT13387) (60 mg/kg ip 3 days on and 3 days off for four cycles) exhibits in vivo antitumor activity in nude BALB/c mice bearing early stage HCT116 human colon carcinoma xenografts.
