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Onapristone

Chemical Structure : Onapristone

CAS No.: 96346-61-1

Onapristone (ZK-89299;ZK-299;AR-18;IVV-1001)

Catalog No.: PC-60075Not For Human Use, Lab Use Only.

A synthetic, steroidal progesterone receptor (PR) antagonist with reduced antiglucocorticoid activity compared to mifepristone..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A synthetic, steroidal progesterone receptor (PR) antagonist with reduced antiglucocorticoid activity compared to mifepristone.

Prostate Cancer

Phase 2 Clinical

Physicochemical Properties

M.Wt 449.635
Formula C29H39NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

11β-(4-(Dimethylamino)phenyl)-17α-hydroxy-17β-(3-hydroxypropyl)-13α-estra-4,9-dien-3-one

References

1. Michna H, et al. Breast Cancer Res Treat. 1989 Dec;14(3):275-88.

2. Schneider MR, et al. J Cancer Res Clin Oncol. 1992;118(3):187-9.

3. Mann GE, et al. Mol Cell Endocrinol. 2013 Aug 25;376(1-2):1-11.

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