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Optovin

Chemical Structure : Optovin

CAS No.: 348575-88-2

Optovin

Catalog No.: PC-43222Not For Human Use, Lab Use Only.

Optovin is a reversible photoactivated TRPA1 ligand that can be photoactivated by violet light, enables light-mediated neuronal excitation in treated animals with EC50 of 2 uM at 387 nm (violet), but not to 485 nm (blue), 560 nm (green) or longer wavelengths.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Optovin is a reversible photoactivated TRPA1 ligand that can be photoactivated by violet light, enables light-mediated neuronal excitation in treated animals with EC50 of 2 uM at 387 nm (violet), but not to 485 nm (blue), 560 nm (green) or longer wavelengths; shows activity on zebrafish, mouse neurons, and recombinant human protein, enables repeated photoactivation of motor behaviors in wild-type zebrafish and mice.

Physicochemical Properties

M.Wt 315.4132
Formula C15H13N3OS2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 37 mg/mL

Chemical Name/SMILES

4-Thiazolidinone, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-

References

1. Kokel D, et al. Nat Chem Biol. 2013 Apr;9(4):257-63.

2. Lu Y, et al. Anesthesiology. 2016 Dec;125(6):1171-1180.

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