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Chemical Structure : Org 34167
Catalog No.: PC-20860Not For Human Use, Lab Use Only.
Org 34167 is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation.
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Org 34167 is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation.
Org 34,167 (30 µM) significantly reduced I h-mediated sag in layer V mPFC pyramidal neurons in female BALB/c mice.
Org 34167 (0.5 mg/kg) reduced marble burying and increased the time spent mobile in the Porsolt swim and tail suspension tests in both male and female BALB/c mice.
Org 34,167 is effective at reducing depressive behaviours in mouse behavioural assays.
| M.Wt | 264.33 | |
| Formula | C17H16N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Paulo Pinares-Garcia, et al. Front Pharmacol. 2023 May 10;14:1159527.
2. Samotaeva IS, et al. Neuroscience. 2013 Jan 29;230:50-5.
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