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Org 42599 free base

Chemical Structure : Org 42599 free base

CAS No.: 501444-88-8

Org 42599 free base

Catalog No.: PC-62756Not For Human Use, Lab Use Only.

Org 42599 is a cell-permeant, allosterically binding, small-molecule agonist of luteinizing hormone (LH) receptor that rescues the folding and cell surface expression mutant mutant human LH receptors A593P and S616Y (EC50=70.8 nM)..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Org 42599 is a cell-permeant, allosterically binding, small-molecule agonist of luteinizing hormone (LH) receptor that rescues the folding and cell surface expression mutant mutant human LH receptors A593P and S616Y (EC50=70.8 nM).

Physicochemical Properties

M.Wt 514.663
Formula C24H30N6O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-amino-N-(tert-butyl)-2-(methylthio)-4-(3-(2-morpholinoacetamido)phenyl)thieno[2,3-d]pyrimidine-6-carboxamide

References

1. Newton CL, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7172-6.

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